Pseudo "fringe sign" in frontal fibrosing alopecia*

An Bras Dermatol. 2017;92(6):891-900. The FS or auriculotemporal syndrome or gustatory sweating results from the salivary stimulus during and immediately after eating, seeing, thinking about, or talking about certain foods. 2,3 The hypothesis is that, after a parotid gland trauma, a lesion would occur to the auriculotemporal branch of the trigeminal nerve, followed by an anomalous and aberrant regeneration of nerve fibers, with the anastomosis of the parasympathetic fibers with sympathetic fibers of the subcutaneous sweat glands and surface blood vessels.4 Consequently, not only is the salivary reflex stimulated during chewing, but also the production of sweat and the cutaneous vasodilation of the affected region.5 The symptoms generally arise about six months after the parotid gland trauma, the time necessary for the regeneration of the damaged nerve, but there are reports of medical conditions that began up to 14 years after the traumatic event.4 The incidence described for FS after parotidectomy is quite variable and depends on the criteria used to reach this diagnosis. One subjective incidence (based on the perception of the patient’s symptoms) was identified between 12.5% and 62%, while an objective incidence (verified by the Minor test) was found between 22% and 98%.3 FS treatment can be challenging and involves clinical and surgical options. Some patients who complain of discomfort due to sweating can be benefitted by the use of topical antiperspirants applied to the affected area, such as aluminum chloride.2 Autologous fat grafts, temporoparietal fascia grafts, muscle flaps, and the use of artificial tissues are example of surgical techniques used in both the prevention and treatment of FS, whose objective is to construct a barrier between the skin and the auriculotemporal nerve in order to avoid anomalous regeneration. 3 Botulinum toxin type A was proposed as a treatment of FS in 1995, and seeks to block the pre-synaptic release of acetylcholine in the neuromuscular and neuroglandular joint,2 in turn provoking a chemical denervation. As an advantage, this is characterized as being a relatively non-invasive therapeutic measure that is safe, effective, and long-lasting. 1-3 In general, the results of botulinum toxin type A for sweating are more prolonged than those obtained in treatments that focus on the reduction of muscular actions. In practice, the successive treatment with the toxin seems to promote a reduction in the severity of the symptoms and the extension of the treated area, as well as space out the period between recurrences. One possible explanation would be the atrophy of the eccrine glands, inhibited for long periods of time.2,5 Disadvantages that may occur include: dry mouth, weakening of the facial muscles, eyelid ptosis, facial paralysis, as well as short-term local reactions of pain, edema, erythema, and ecchymoses. Allergic reactions and the development of resistance to botulinum toxin type A can occur, and in these cases, the use of botulinum toxin type B would be a plausible alternative.1,2 q